IKAROS re-expression modulates transcriptional networks in IKZF1-mutant Ph+ B-ALL
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 64 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Topic
- Acute lymphoblastic leukemiaThis series is part of our curated briefing on it.
- Samples
- 64 samples: 26 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- IKAROS Gene Regulatory Network Reveal ERG as a Vulnerability in B-cell Acute Lymphoblastic LeukemiabioRxiv : the preprint server for biology · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE310976_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1367648 and SRA study SRP647451. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 52 samples.
How we read this: 26 replicated groups read from 64 sample titles; they account for 52 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9311260 ATAC-seq of MXP5 control rep1 ATAC-seq of MXP5 control
- GSM9311261 ATAC-seq of MXP5 control rep2 ATAC-seq of MXP5 control
- GSM9311262 ATAC-seq of MXP5 IK1 rep1 ATAC-seq of MXP5 IK1
- GSM9311263 ATAC-seq of MXP5 IK1 rep2 ATAC-seq of MXP5 IK1
- GSM9311264 ATAC-seq of PDX2 control rep1 ATAC-seq of PDX2 control
- GSM9311265 ATAC-seq of PDX2 control rep2 ATAC-seq of PDX2 control
- GSM9311266 ATAC-seq of PDX2 IK1 rep1 ATAC-seq of PDX2 IK1
- GSM9311267 ATAC-seq of PDX2 IK1 rep2 ATAC-seq of PDX2 IK1
- GSM9311399 ChIP-seq of IKAROS in MXP5 control rep1 ChIP-seq of IKAROS in M…
- GSM9311400 ChIP-seq of IKAROS in MXP5 control rep2 ChIP-seq of IKAROS in M…
- GSM9311401 ChIP-seq of IKAROS in MXP5 IK1 rep1 ChIP-seq of IKAROS in M…
- GSM9311402 ChIP-seq of IKAROS in MXP5 IK1 rep2 ChIP-seq of IKAROS in M…
- GSM9311403 ChIP-seq of ERG in MXP5 control rep1 ChIP-seq of ERG in MXP5…
- GSM9311404 ChIP-seq of ERG in MXP5 control rep2 ChIP-seq of ERG in MXP5…
- GSM9311405 ChIP-seq of ERG in MXP5 IK1 rep1 ChIP-seq of ERG in MXP5…
- GSM9311406 ChIP-seq of ERG in MXP5 IK1 rep2 ChIP-seq of ERG in MXP5…
- GSM9311407 ChIP-seq of CTCF in MXP5 control rep1 ChIP-seq of CTCF in MXP…
- GSM9311408 ChIP-seq of CTCF in MXP5 control rep2 ChIP-seq of CTCF in MXP…
- GSM9311409 ChIP-seq of CTCF in MXP5 IK1 rep1 ChIP-seq of CTCF in MXP…
- GSM9311410 ChIP-seq of CTCF in MXP5 IK1 rep2 ChIP-seq of CTCF in MXP…
- GSM9311411 ChIP-seq of H3K27ac in MXP5 control rep1 ChIP-seq of H3K27ac in …
- GSM9311412 ChIP-seq of H3K27ac in MXP5 control rep2 ChIP-seq of H3K27ac in …
- GSM9311413 ChIP-seq of H3K27ac in MXP5 IK1 rep1 ChIP-seq of H3K27ac in …
- GSM9311414 ChIP-seq of H3K27ac in MXP5 IK1 rep2 ChIP-seq of H3K27ac in …
- GSM9311415 ChIP-seq of H3K36me3 in MXP5 control rep1 ChIP-seq of H3K36me3 in…
- GSM9311416 ChIP-seq of H3K36me3 in MXP5 control rep2 ChIP-seq of H3K36me3 in…
- GSM9311417 ChIP-seq of H3K36me3 in MXP5 IK1 rep1 ChIP-seq of H3K36me3 in…
- GSM9311418 ChIP-seq of H3K36me3 in MXP5 IK1 rep2 ChIP-seq of H3K36me3 in…
- GSM9311419 ChIP-seq of H3K4me1 in MXP5 control rep1 ChIP-seq of H3K4me1 in …
- GSM9311420 ChIP-seq of H3K4me1 in MXP5 control rep2 ChIP-seq of H3K4me1 in …
- GSM9311421 ChIP-seq of H3K4me1 in MXP5 IK1 rep1 ChIP-seq of H3K4me1 in …
- GSM9311422 ChIP-seq of H3K4me1 in MXP5 IK1 rep2 ChIP-seq of H3K4me1 in …
- GSM9311423 Input for MXP5 ChIP-seq control rep1
- GSM9311424 HiChIP of H3K27ac in MXP5 control rep1 HiChIP of H3K27ac in MX…
- GSM9311425 HiChIP of H3K27ac in MXP5 control rep2 HiChIP of H3K27ac in MX…
- GSM9311426 HiChIP of H3K27ac in MXP5 IK1 rep1 HiChIP of H3K27ac in MX…
- GSM9311427 HiChIP of H3K27ac in MXP5 IK1 rep2 HiChIP of H3K27ac in MX…
- GSM9313252 RNA-seq of PDX2 bulk sample
- GSM9313253 RNA-seq of MXP5 bulk sample
- GSM9313254 RNA-seq of LAX7 bulk sample
+ 24 more — browse all 64 samples with per-sample file links →
- GSE13425 Expression data from ALL patients included in the set used to construct a classification signature (COALL cohort) 190 samples same disease briefing
- GSE12995 Expression data for diagnosis acute lymphoblastic leukemia samples 175 samples same disease briefing
- GSE160298 The chromatin accessibility landscape of T-Cell Acute Lymphoblastic Leukemia 80 samples same disease briefing
- GSE154675 PHF6 Interacts with LMO2 During Normal Haematopoiesis and in Leukaemia and Regulates the Level of Gene Expression and Genome Integrity 41 samples same disease briefing
- GSE115656 Alternative splicing analysis of pediatric B-cell acute lymphoblastic leukemia compared to normal bone marrow derived pro-B cells 38 samples same disease briefing
- GSE193713 Genome-wide maps of chromatin state for histone modifications and chromatin remodeling factors in WT and PHF6-KO conditions in Jurkat T-ALL cells. 20 samples same disease briefing
- GSE18198 Expression profile of human T-ALL cell lines treated with DMSO or SAHM1 12 samples same disease briefing
- GSE310890 IKAROS re-expression modulates transcriptional networks in IKZF1-mutant Ph+ B-ALL [ChIP-Seq] 25 samples shares ikaros, b-all, re-expression, ikzf1-mutant, modulates, networks
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.