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Comparison of the kidney transcriptome of 45 days old principal cell-specific Tsc1 knockout (Tsc1f/f/Aqp2 Cre) vs Wild-type (WT) mice.

GSE311309 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/02/18 Platform GPL17021
Summary
Tuberous sclerosis complex is a genetic disorder that affects multiple organs. In the kidney, it presents as hamartomas and cysts. The epithelium of TSC renal cysts is primarily composed of A-intercalated cells. In these studies, we compared the renal transcriptomes of 45 days old principal cell-specific Tsc1 knockout (Tsc1f/f/Aqp2 Cre; Tsc1 KO) and WT mice.
Published in
The critical role of the proto-oncogene c-Kit in TSC renal cystogenesis
Zahedi K, Barone S, Brooks M et al. · EMBO molecular medicine 2026 · PMID 41429944 · doi:10.1038/s44321-025-00360-x
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Direct links to NCBI, no account and no request form: the whole study as GSE311309_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1368913 and SRA study SRP648630. Searching any of these in the dataset finder brings you back here.

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