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Transcription factor 21 deletion from podocyte precursors as a model for congenital nephrotic syndrome

GSE311499 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2026/05/04 Platform GPL21103
Summary
Here, we establish a mouse model of congenital nephrotic syndrome (NS) by genetic deletion of transcription factor 21 (Tcf21), a gene required for normal podocyte development, selectively from early podocyte precursors. Single cell transcriptomics of kidneys from these mice capture glomerular and tubulointerstitial changes that occur early in the course of NS and provide additional insights into: 1) the regulation of podocyte development and function by TCF21, 2) the effects of podocyte injury on other glomerular cells, and 3) the tubulointerstitial changes that occur in response to the glomerular dysfunction and associated massive proteinuria of podocytopathies.
Published in
Transcription factor 21 deletion from podocyte precursors as a model for congenital nephrotic syndrome
Dalal V, Zhou Y, Deb DK et al. · American journal of physiology. Renal physiology 2026 · PMID 42090190 · doi:10.1152/ajprenal.00490.2025
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Also filed as BioProject PRJNA1369560 and SRA study SRP648990. Searching any of these in the dataset finder brings you back here.

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