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Transcriptomic Profiling of RAW264.7 Cells During RANKL-Induced Osteoclast Differentiation

GSE311709 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/04/09 Platform GPL24247
Summary
Osteoclast differentiation is primarily driven by RANKL stimulation, yet the transcriptional remodeling associated with this process remains incompletely characterized. This dataset profiles global gene expression changes in RAW264.7 macrophages under two conditions: untreated control and RANKL-induced osteoclast differentiation. The transcriptomic comparison reveals key pathways associated with osteoclast formation, including osteoclast-related gene activation, metabolic remodeling, and oxidative stress–related signaling. These data serve as the baseline reference for subsequent uridine-intervention analyses.
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Direct links to NCBI, no account and no request form: the whole study as GSE311709_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1370319. Searching any of these in the dataset finder brings you back here.

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