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Piezo1 Knockdown Activates PI3K/AKT and Enhances SPP1 to Drive M2 Macrophage Polarization and Reduce Cardiac Inflammation

GSE311976 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/12/29 Platform GPL24247
Summary
We have successfully established a mouse model with myeloid cell-specific knockdown of Piezo1. The intraperitoneal injection of lipopolysaccharide (LPS) resulted in a significant increase in cardiac macrophage infiltration, as well as an increase in the expression of inflammatory factors and the inflammatory response. However, myeloid cell-specific knockdown of Piezo1 impaired this response, leading to an increase in macrophage polarization towards the M2 type and the decreased inflammatory response. As a result, myocardial injury caused by sepsis was attenuated. We have also demonstrated that the PI3K/AKT pathway is significantly activated after Piezo1 knockdown, resulting in reduced myocardial dysfunction.
Published in
Piezo1 knockdown activates PI3K/AKT and enhances SPP1 to drive M2 macrophage polarization and reduce cardiac inflammation
Zhang Y, Zhang Y, Song J et al. · Scientific reports 2026 · PMID 41507437 · doi:10.1038/s41598-025-34794-7
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Also filed as BioProject PRJNA1372009 and SRA study SRP650268. Searching any of these in the dataset finder brings you back here.

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