← BioTransfer GEO Dataset Finder
GEO series

Transcriptional profiling of estrogen-responsive uterine genes in Rptorf/f Pgrcre/+ mice

GSE312338 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/05/15 Platform GPL24247
Summary
To investigate the molecular mechanisms by which mTORC1 signaling inactivation contributes to thin endometrium, we performed uterine transcriptomic profiling in ovariectomized Rptorf/f Pgrcre/+ mice (n=3) and Rptorf/f control (n=3) mice 24 hours after estrogen stimulation. RNA was extracted with TRIzol, and quality-confirmed (A260/280 >1.8, RIN >8.0). Stranded mRNA libraries were prepared (TruSeq Stranded mRNA LT Kit) and sequenced on Illumina Novaseq 6000. Reads were aligned to GRCm38.p6 (HISAT2), and gene expression was quantified as FPKM (Cufflinks) and read counts (HTSeq-count).
Published in
mTORC1 as a metabolic rheostat coordinates hormonal signals and cellular proliferation to sustain endometrial competence
Sun Y, Wan S, Zhao M et al. · Cellular & molecular biology letters 2026 · PMID 41826809 · doi:10.1186/s11658-026-00888-x
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE312338_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1373111 and SRA study SRP651007. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 6 more — browse all 6 samples with per-sample file links →

Similar datasets

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.