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The RING E3 Ligase RLIM Drives Oxidative Stress-Induced Stem Cell Dysfunction through MDM2-p53 Signaling

GSE312500 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/06/01 Platform GPL34284
Summary
Chronic diabetic ulcers present a persistent challenge due to delayed wound healing. At the wound site, oxidative stress impairs stem cell survival and differentiation, accelerates senescence, and impairs autophagy. RLIM was identified as a critical regulator in human umbilical cord mesenchymal stem cells (hUCMSCs), where oxidative stress-induced RLIM upregulation leads to MDM2 degradation and stabilization of p53. Functionally, RLIM upregulation under oxidative stress inhibited autophagy, induced cellular senescence, and significantly impaired angiogenesis, cell migration, and immunomodulatory functions, ultimately hindering diabetic wound healing in vivo. These results highlight the RLIM-MDM2-p53 signaling axis as a pivotal pathway governing stem cell senescence and function under oxidative stress, offering promising therapeutic targets to enhance stem cell-based approaches for diabetic wound repair.
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Also filed as BioProject PRJNA1374069 and SRA study SRP651358. Searching any of these in the dataset finder brings you back here.

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