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4-OI treatment inhibit LPS-induced neutrophil inflammatory responses

GSE312519 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2025/12/30 Platform GPL24247
Summary
Our in vitro cell research has revealed that LPS stimulation can induce the upregulation of the immune response gene 1 (Irg1) in neutrophils. Itaconic acid is a metabolic derivative generated by Irg1,4-octyl itaconate, which is exogenous itaconate, can exert protective effects in acute colitis. we utilized RNA sequencing-based omics analysis to explore the impact of 4OI treatment on the activation of inflammatory responses in neutrophils and the underlying mechanisms.Transcriptomic analysis revealed that 4-OI suppresses inflammatory signaling pathways including NF-κB and Toll-like receptor pathways.The experiment was divided into 3 groups, including the control group, the LPS stimulation experimental group, and the 4-OI treatment group.
Published in
Neutrophil Irg1/itaconate axis protects against experimental colitis by suppressing local inflammation and maintaining hematopoietic homeostasis
Zhao N, Wang G, Long S et al. · Molecular biomedicine 2025 · PMID 41417165 · doi:10.1186/s43556-025-00390-4
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Also filed as BioProject PRJNA1374095 and SRA study SRP651388. Searching any of these in the dataset finder brings you back here.

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