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Transcriptomic profiling of brown adipose tissue in high-fat diet-induced obese mice following Pu-erh tea extract intervention

GSE312855 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/12/12 Platform GPL34290
Summary
Background: Obesity driven by high-fat diet (HFD) is a global public health concern, and Pu-erh tea extract (PTE) exhibits anti-obesity potential, but its regulatory mechanism on brown adipose tissue (BAT) metabolism remains unclear. Transcriptomic analysis of BAT is critical to reveal PTE-mediated metabolic remodeling. Methods: C57BL/6J mice were divided into HFD (high-fat diet) and HFD+PTE groups. BAT samples were collected after 16-week intervention for RNA sequencing. Results: Transcriptomic data showed 623 differentially expressed genes (DEGs) in HFD+PTE vs HFD groups, mainly enriched in cAMP/Calcium signaling, Biosynthesis of unsaturated fatty acids, and Glycerolipid metabolism pathways. Value: This dataset provides transcriptomic evidence for PTE regulating BAT function, complementing our previously deposited gut microbiota 16S rRNA data, and facilitating research on natural product-mediated metabolic regulation.
Published in
Pu-erh tea attenuates obesity by remodeling gut microbiota and activating energy expenditure
Jiang X, Wu F, Xu M et al. · Frontiers in microbiology 2025 · PMID 41623636 · doi:10.3389/fmicb.2025.1752456
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Also filed as BioProject PRJNA1377520 and SRA study SRP653315. Searching any of these in the dataset finder brings you back here.

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