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Transcript landscape in the heart of inducible cardiomyocyte-specific Immt knockout mice

GSE312894 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/04/01 Platform GPL24247
Summary
Immt gene encodes Mic60 protein which is a main component of the mitochondrial contact site and cristae organizing system (MICOS) protein complex. The MICOS complex plays pivotal roles for crisa juction formation and connection of inner mitochondrial membrane and outer mitocondrial membrane of mitochondria. Although it is well known that the ristae are crucial for energy production by OXPHOS, it is still precisely unknown how the Mic60 is important in the adult matured cardiomyocytes in vivo. To expand our knowledge about the Mic60 functions in the adult mouse heart, we utilized inducible cardiomyocyte-specific Immt gene knockout mice and conducted bulk RNA-seq with the hearts. Our data highlights the mitochondria stress response at transcript level in the hearts.
Published in
Heart-Specific and Conditional Deletion of the Immt Gene Reveals Its Role in Regulating Mitochondrial Structure and Total Heart Metabolism
Kuwabara Y, Keezer C, Lin SJ et al. · Cells 2026 · PMID 41892295 · doi:10.3390/cells15060505
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Also filed as BioProject PRJNA1377571 and SRA study SRP653421. Searching any of these in the dataset finder brings you back here.

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