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Single-Cell RNA Sequencing of Galt Gene-Edited Mouse Liver Tissue

GSE313046 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2026/03/12 Platform GPL24247
Summary
This dataset contains single-cell RNA sequencing data from liver tissues of Galt gene-edited (GAL) mice and wild-type (WT) mice. The samples were collected for the investigation of molecular changes induced by Galt gene mutations, specifically focusing on liver injury. The dataset includes gene expression profiles of individual cells and enables the study of cell-type-specific responses, immune cell changes, and alterations in key cellular pathways. This dataset is useful for further understanding the pathophysiology of liver injury associated with Galt gene mutations and provides a resource for research into the molecular mechanisms of galactosemia.
Published in
Single-cell transcriptomics reveals mechanisms of Galt gene editing-induced liver injury involving HGF-VEGF-mediated intercellular signaling in mice
Li Z, Wang N, Ruan H et al. · Frontiers in cell and developmental biology 2025 · PMID 41624789 · doi:10.3389/fcell.2025.1729321
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Direct links to NCBI, no account and no request form: the whole study as GSE313046_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1378184 and SRA study SRP653789. Searching any of these in the dataset finder brings you back here.

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