GEO series
Effect of different ECM proteins on cholangiocytes phenotype in a double-spheroids model
GSE313120
Mus musculus
Expression profiling by high throughput sequencing
10 samples
2026/05/31
GPL34290
Summary
Cholangiocyte plasticity is strongly influenced by the extracellular matrix (ECM) niche. To investigate how specific ECM components modulate cholangiocyte identity, we performed bulk RNA sequencing on double-spheroid cultures composed of normal mouse cholangiocytes embedded either in collagen I alone or in a laminin-rich matrix. Laminin-containing ECM preserves cholangiocyte identity and limits hepatocyte-like transcriptional programs. This dataset provides transcriptional profiling of cholangiocytes exposed to distinct ECM environments and supports mechanistic studies on ECM-driven regulation of ductular reaction fate.
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