GEO series

Chromatin accessibility analysis in lipid droplet-laden macrophages with or without SLC27A1 silencing (ATAC-seq)

GSE313205 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 6 samples Submitted 2026/01/31 Platform GPL24247

Summary

The obesity epidemic is associated with increased incidence of colorectal cancer liver metastasis (CRLM) and the local recurrence following CRLM resection. Here, we demonstrate that M2 type tumor-associated macrophages (TAMs) significantly accumulate within liver metastases in high-fat-diet-induced obese mice, and thus accelerating the development of CRLM. The TAMs from mice with high-fat diet facilitate the expansion of lipid droplets by upregulating SLC27A1, and as a result, M2 polarization is promoted. Mechanistically, SLC27A1 binds with PLIN2, a lipid droplet coat protein, to inhibit its degradation via chaperone-mediated autophagy. Moreover, the number of SLC27A1+ TAMs is significantly increased in obese patients with CRLM, suggesting that the mechanism revealed here likely plays a role in the progression of human CRLM and represents a potential target for treatment.

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Also filed as BioProject PRJNA1378789 and SRA study SRP654051. Searching any of these in the dataset finder brings you back here.

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