KAT6A is essential for developmental control gene expression in neural stem and progenitor cells

Heterozygous mutations in the MYST family histone acetyltransferase gene, KAT6A (MOZ, MYST3) cause the human congenital disorders characterised by intellectual disability, Arboleda-Tham syndrome (KAT6A syndrome). In this dataset, we used neural stem cells isolated from Kat6a+/+, Kat6a+/– and Kat6a–/– E12.5 mouse embryos cultured under proliferating and differentiating conditions to assess the effects of loss of one or both alleles of Kat6a on neural stem and progenitor proliferation and differentiation.