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Activating transcription factor 6α governs stress-adaptive pancreatic β-cell mass expansion through the coordination of proliferation and survival

GSE314201 Mus musculus Expression profiling by high throughput sequencing 5 samples Submitted 2026/07/01 Platform GPL24247
Summary
We have employed a single cell RNA sequencing analysis using 10x Genomics scRNA-seq to investigate the role of ATF6α in pancreatic β-cells under chronic metabolic stress.ATF6α initiates a key branch of the unfolded protein response and has been implicated in β-cell survival, apoptosis, insulin secretory function, and glucose homeostasis. This study provides new insights into how ATF6α coordinate stress-adaptative transcriptional networks of β-cells leading to β-cell mass expansion under chronic metabolic stress, that contributes to the better understanding of preservation strategy of functional β-cell mass in diabetes.
Published in
Activating Transcription Factor 6α Governs Stress-Adaptive Pancreatic β-Cell Mass Expansion by Coordinating Proliferation and Survival
Otani D, Murakami T, Fauzi M et al. · Diabetes 2026 · PMID 41996190 · doi:10.2337/db26-0048
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Also filed as BioProject PRJNA1390250 and SRA study SRP656084. Searching any of these in the dataset finder brings you back here.

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