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Mortality Risk-Stratified Septic Serum Depresses Contractility and Mitochondrial Function in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes [SOMAscan]

GSE314568 Homo sapiens (human) Protein profiling by protein array 120 samples Submitted 2026/09/01 Platform GPL36446

At a glance

human · 120 samples

Organism: Homo sapiens (human)
Samples: 120 samples
Data you can get: A processed table (series matrix) and supplementary files from NCBI.

Summary (written by the submitters)

We sought to define proteomic differences in mortality risk-stratified septic serum as a prelude to translational modeling of cardiomyocyte pathobiology in septic shock. Previously banked serum from children with septic shock (n=120) was stratified by Pediatric Sepsis Biomarker Risk Model (PERSEVERE) II mortality probability as low, intermediate, or high risk.

Read the full summary ↓

We conducted aptamer-based proteomic analysis of septic serum to determine differentially expressed proteins in children with high compared to low mortality risk. Sera from patients designated as PERSEVERE II high mortality risk demonstrated a global proteomic shift relative to those from patients with low mortality risk, and IL-6 and IL-8 were prominently differentially expressed proteins in children with high mortality probability. Downstream proteomic analyses for differential protein expression focused on comparing samples with HIGH and LOW PERSEVERE II risk, adjusting for site, age, and plate.

This dataset

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Direct links to NCBI, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓

2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need.

All supplementary files ↗

3 · The original raw files

Whole study · RAW.tar

Everything the authors deposited as one archive (GSE314568_RAW.tar), including the raw array or instrument files. Can be large; the picker in step 2 takes just the samples you need.

Whole study · RAW.tar ↓

Also filed as BioProject PRJNA1391528. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗

Samples in this study

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