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Aortic Single-Cell Transcriptome Analysis Reveals ApoE Isoform-Specific Effects in Vascular Disease Modulation

GSE314969 Mus musculus Expression profiling by high throughput sequencing 3 samples Submitted 2026/07/01 Platform GPL24247
Summary
The human APOE gene is polymorphic with 3 major alleles that encode apolipoprotein (apo) E2, apoE3, and apoE4. Both apoE2 and apoE4 are associated with increased atherosclerosis risk. This study uses Human APOE2, APOE3, and APOE4 gene replacement mice and scRNA-seq to delineate the mechanisms underlying this association, with a focus on how the various apoE isoforms influence the cell repertoire in the vessel wall.
Published in
Aortic Single-Cell Transcriptome Analysis Reveals ApoE-Isoform-Specific Influences on Vascular Disease
Hui DY, Alagarsamy J, Haller A et al. · International journal of molecular sciences 2026 · PMID 42353333 · doi:10.3390/ijms27125619
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Also filed as BioProject PRJNA1393366 and SRA study SRP657965. Searching any of these in the dataset finder brings you back here.

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