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The effects of oleic acid diet on ovarian cancer tumor growth in murine xenograft model

GSE315189 Mus musculus Expression profiling by high throughput sequencing 7 samples Submitted 2026/03/31 Platform GPL34290
Summary
Oleic acid is an unsatuarated fatty acid that is converted by SCD1 (Stearoyl-CoA Desaturase 1), which is highly expressed in in ovarian cancer and has protective effect on cancer cell survival. We here report oleic acid high diet has upregulated serveral cell cycle related pathways such as E2F targets, mitotic spindle and G2M targets to promote cell proliferation in murine xenograft model.
Published in
Oleic acid fuels cisplatin-resistant ovarian cancer through FABP4-driven lipid uptake
Isac AM, Valdivia A, Zha D et al. · Molecular metabolism 2026 · PMID 42025693 · doi:10.1016/j.molmet.2026.102374
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Also filed as BioProject PRJNA1395100 and SRA study SRP658684. Searching any of these in the dataset finder brings you back here.

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