← BioTransfer GEO Dataset Finder
GEO series

An α-specific PI3K inhibitor improves chemotherapy efficacy by inhibiting hepatic stellate cell activation in liver cancer

GSE315789 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/01/12 Platform GPL24676
Summary
The poor response to current systemic treatments in liver cancer has been associated with the activation of cancer-associated fibroblasts (CAFs). Herein, we aimed to investigate the effects of chemotherapy on hepatic stellate cells (HSCs), the main origin of CAFs in liver cancer. In vitro experiments demonstrated that cisplatin activated HSCs through a paracrine effect from HCC tumour cells while the mechanism remains unknown. RNA sequencing of human primary HSCs incubated in untreated or cisplatin-pretreated Huh7 conditioned medium revealed a PI3K signaling pathwayof HSC activation. Further analyses showed that PI3K pathway, especially PI3K p110a is crucial for HSC activation and by targeting PI3K p110a, HSC activation induced by cisplatin can be completely inhibited and improves cisplatin therapeutic efficacy.
Published in
An α-specific PI3K inhibitor improves chemotherapy efficacy by inhibiting hepatic stellate cell activation in liver cancer
Ruan Q, Chen T, Kim M et al. · Hepatology (Baltimore, Md.) 2025 · PMID 41397162 · doi:10.1097/HEP.0000000000001639
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE315789_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1399175 and SRA study SRP660212. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 6 more — browse all 6 samples with per-sample file links →

Similar datasets

Search all human RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.