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Tkt knockdown impaired NADPH production in CD8+ T cells

GSE315826 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/02/08 Platform GPL28330
Summary
Transketolase (TKT) is a key enzyme in the non-oxidative pentose phosphate pathway. However, the impact of Taldo1 disruption on CD8+ T cell differentiation and function remains undefined. Here, we found that knockdown of Taldo1 in CD8+ T cells impairs NADPH production, causes ribose-5-phosphate accumulation, elevates oxidative stress, reduces lipid synthesis, induces mitochondrial dysfunction, and compromises effector cell proliferation, cytokine production, and antitumor efficacy, whereas enhancing Taldo1 promotes memory T cell differentiation, persistence, and recall responses during immune challenges.
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Also filed as BioProject PRJNA1397938 and SRA study SRP659572. Searching any of these in the dataset finder brings you back here.

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