← BioTransfer GEO Dataset Finder
GEO series

TEAD-independent mechanisms of YAP function in cardiomyocytes

GSE315945 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/01/20 Platform GPL24247
Summary
Adult mammalian hearts exhibit limited regenerative capacity due to the restricted renewal of cardiomyocytes. Recent studies reveal that mammalian hearts exhibit transient regenerative potential within a short time frame after birth, suggesting a regulatory mechanism that prevents adult hearts from initiating a regenerative response to cardiac injury. Here, we discovered that an active form of YAP, named YAP6SA, which is not inhibited by the Hippo signaling pathway and does not interact with TEADs, induces cardiomyocyte cell cycle re-entry. In addition, YAP6SA interacts with scaffold protein MPDZ to regulate Rho GTPases and promote cell cycle progression in cardiomyocytes (CMs). Importantly, YAP6SA overexpression is well tolerated in mammalian hearts. These findings provide new insights into YAP function in cardiomyocytes.
Published in
TEAD-independent mechanisms of YAP function in cardiomyocyte cell cycle reentry
Xie B, Steimle J, Deshmukh V et al. · Life science alliance 2026 · PMID 41577381 · doi:10.26508/lsa.202503496
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE315945_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1399992 and SRA study SRP660692. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 6 more — browse all 6 samples with per-sample file links →

Similar datasets

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.