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M-cadherin regulates the formation of adherens junctions and secondary myofibers during fetal myogenesis to determine adult myofiber number and muscle mass

GSE315987 Mus musculus (mouse) RNA-seq (gene expression) 88 samples Submitted 2026/01/13 Platform GPL17021
At a glance

RNA-seq (gene expression) · mouse · 88 samples

What it is
RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
Organism
Mus musculus (mouse)
Samples
88 samples: 18 conditions, mostly with about 5 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
M-cadherin regulates the formation of adherens junctions and secondary myofibers during fetal myogenesis to determine adult myofiber number and muscle massStem cell reports · 2026
Summary (written by the submitters)
Cadherin-mediated adhesion of skeletal muscle stem cells within their niche is necessary for normal adult muscle maintenance and regeneration; however, the role of cadherins in regulating muscle development and growth has not yet been elucidated. Here, we show that M-cadherin protein is localized to adherens junctions in developing muscle, and that deletion of CDH15, the gene encoding M-cadherin, results in the loss of adherens junctions in fetal mouse muscle.
Read the full summary ↓
This loss of adherens junctions is associated with reduced secondary myofiber formation, ultimately resulting in reduced adult myofiber number and muscle mass. Concordantly, via large-scale exome sequencing, we found that humans with predicted loss-of-function variants in the CDH15 gene had significantly reduced lean mass, indicating that M-cadherin functions to regulate muscle mass in both mice and humans. Overall, these data highlight a previously unrecognized role of M-cadherin in controlling fetal myofiber formation and establishment of adult muscle mass.
Published in
M-cadherin regulates the formation of adherens junctions and secondary myofibers during fetal myogenesis to determine adult myofiber number and muscle mass
Golann DR, Ferrara PJ, Khan NP et al. · Stem cell reports 2026 · PMID 41687617 · doi:10.1016/j.stemcr.2026.102812
This dataset
Open GSE315987 in finder → Find more mouse RNA-seq datasets →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE315987_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.

Also filed as BioProject PRJNA1400065 and SRA study SRP660748. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 41687617) ↗
Study design
18 conditions, mostly with about 5 replicates each
Cdh15 KO_heart ×5 WT_heart ×5 Cdh15 KO_kidney ×5 Cdh15 KO_live ×5 WT_live ×5 Cdh15 KO_lung ×5 WT_lung ×5 Cdh15 KO_spleen ×5 +10 more

Supports a between-group comparison across 88 samples.

How we read this: 18 replicated groups read from 88 sample titles; they account for 88 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study

+ 48 more — browse all 88 samples with per-sample file links →

Datasets on a similar topic

Search all mouse RNA-seq datasets in GEO →

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