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Association between elevated expression of GDF15/GFRAL and sarcopenia risk

GSE316316 Mus musculus Expression profiling by high throughput sequencing 5 samples Submitted 2026/03/11 Platform GPL24247
Summary
Glial cell line-derived neurotrophic factor family receptor α-like (GFRAL) is the exclusive receptor for growth differentiation factor 15 (GDF15) and plays distinct roles in various diseases. However, its impact on sarcopenia remains poorly understood. This study, comprising participants of White British and Chinese descent, demonstrated that elevated serum levels of GDF15 and its receptor GFRAL are associated with an increased risk of sarcopenia, particularly among individuals with low physical performance. While GDF15 exerts effects across the whole population, GFRAL appears to be more detrimental in women. Complementary single-cell RNA sequencing and immunohistochemical analyses in animal models further support the involvement of the GDF15–GFRAL axis in mediating skeletal muscle damage. These findings highlight the clinical and preventive relevance of the GDF15–GFRAL axis and underscore the need for future mechanistic studies to elucidate its role in sarcopenia.
Published in
Association between elevated expression of GDF15/GFRAL and sarcopenia risk
Zhang ZS, Fan PD, Zhang WY et al. · iScience 2026 · PMID 41797911 · doi:10.1016/j.isci.2026.115023
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Also filed as BioProject PRJNA1402284 and SRA study SRP661825. Searching any of these in the dataset finder brings you back here.

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