Loss of maternal PADI6 disrupts DNA methylation and genomic imprinting maintenance in late preimplantation mouse embryos.
DNA methylation · mouse · 19 samples
- What it is
- DNA methylationChemical marks on DNA that help switch genes on or off.
- Organism
- Mus musculus (mouse)
- Samples
- 19 samples: 19 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Loss of maternal PADI6 disrupts DNA methylation and genomic imprinting maintenance in late preimplantation mouse embryosEpigenetics & chromatin · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE316549_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for beta-value tables or raw IDAT files among the supplementary files.
Also filed as BioProject PRJNA1403374 and SRA study SRP662682. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 9 samples read as cases, 10 as controls.
How we read this: Read from 19 sample titles: 19 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9455735 m2 Padi6 mutant blastocyst
- GSM9455736 m3 Padi6 mutant blastocyst
- GSM9455737 m4 Padi6 mutant blastocyst
- GSM9455738 m5 Padi6 mutant blastocyst
- GSM9455739 m6 Padi6 mutant blastocyst
- GSM9455740 m7 Padi6 mutant blastocyst
- GSM9455741 m8 Padi6 mutant blastocyst
- GSM9455742 m9 Padi6 mutant blastocyst
- GSM9455743 m10 Padi6 mutant blastocyst
- GSM9455744 w1 control blastocyst
- GSM9455745 w2 control blastocyst
- GSM9455746 w3 control blastocyst
- GSM9455747 w4 control blastocyst
- GSM9455748 w5 control blastocyst
- GSM9455749 w6 control blastocyst
- GSM9455750 w7 control blastocyst
- GSM9455751 w8 control blastocyst
- GSM9455752 w9 control blastocyst
- GSM9455753 w10 control blastocyst
- GSE263902 The translational landscape of mouse oocytes and preimplantation embryos revealed by high-resolution ribosome profiling 272 samples shares preimplantation, embryos
- GSE229238 DNA methylation constrains nucleosome retention in sperm and H3K4 methylation deposition in early mouse embryos [RNA-seq 2] 42 samples shares methylation, embryos
- GSE295196 m6A RNA methylation in the maintenance of X-chromosome inactivation and X to autosome dosage compensation in early embryogenesis [RNA-Seq] 14 samples shares methylation, maintenance
- GSE262791 LaminB1 DamID, RNA-seq and Genome-wide analysis of replication timing in RIF1 depleted preimplantation mouse embryos 468 samples shares preimplantation, embryos
- GSE293592 Maternal immune activation delays DNA methylation and physiological maturation of cortical excitatory neurons 106 samples shares methylation, maternal
- GSE295926 Maternal Vitamin C Deficiency and Genetic Risk Factors Contribute to Congenital Malformations through Dysregulation of DNA Methylation. 67 samples shares methylation, maternal
- GSE337304 Reciprocal, methylation-dependent binding of Zfp57 and Gzf1 safeguards Dlk1-Dio3 imprinting during developmental reprogramming 64 samples shares methylation, imprinting
- GSE264193 H3K27 dimethylation dynamics reveal stepwise establishment of facultative heterochromatin in early mouse embryos [ChIP-seq] 57 samples shares methylation, embryos
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.