GEO series
Gene expression induced by DREADD activation in cultured astrocytes
GSE316854
Mus musculus
Expression profiling by high throughput sequencing
18 samples
2026/01/22
GPL28330
Summary
Astrocytes are essential regulators of neuronal function and brain homeostasis. While chemogenetic strategies, such as DREADD (Designer Receptors Exclusively Activated by Designer Drugs), are frequently employed to specifically modulate astrocyte activity, the molecular mechanisms accompanying their activation remain incompletely understood. Here, we characterized the transcriptional responses of cultured cortical astrocytes to DREADD stimulation. These findings provide a molecular framework for interpreting astrocytic DREADD manipulations.
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