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Gene expression analysis of TGFβ1-stimulated fibroblasts to assess anti-fibrotic effects of the bisubstrate-like NNMT inhibitor II559

GSE317322 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2026/01/22 Platform GPL34284
Summary
Fibroblast activation drives tissue fibrosis and is often mediated by TGFβ1 signaling. Human fibroblasts were pre-treated with the NNMT inhibitor II559 for 12 hours, followed by TGFβ1 stimulation for 72 hours. Transcriptomic profiling revealed that II559 prevented pro-fibrotic gene expression, providing a resource for understanding how NNMT inhibition modulates fibroblast activation and fibrotic remodeling.
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Also filed as BioProject PRJNA1406736 and SRA study SRP665640. Searching any of these in the dataset finder brings you back here.

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