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Ganoderic Acid A alleviates ulcerative colitis by inhibiting the IL-17 signaling pathway via targeting RORA

GSE317392 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2026/01/31 Platform GPL13112
Summary
Ulcerative colitis (UC), a chronic inflammatory bowel disease, poses a significant global public health burden, a challenge compounded by the limited availability of effective treatments. Ganoderic acid A (GAA), which is a unique secondary metabolite in Ganoderma lucidum, has demonstrated anti-inflammatory, anti-tumor, antioxidant, and lipid-lowering activities. However, the role and mechanism of GAA in UC are not fully understood. In this study, we aimed to explore the role and involved mechanisms of GAA in UC.
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Also filed as BioProject PRJNA1404442 and SRA study SRP665051. Searching any of these in the dataset finder brings you back here.

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