Dietary Poricoic acid A alleviates depressive-like behaviors by targeting the gut microbiota-immune axis
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 12 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE327915_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1452981 and SRA study SRP691554. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 12 sample titles: 12 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9668409 Control1_FPKM
- GSM9668410 Control2_FPKM
- GSM9668411 Control3_FPKM
- GSM9668412 Control4_FPKM
- GSM9668413 Model1_FPKM
- GSM9668414 Model2_FPKM
- GSM9668415 Model3_FPKM
- GSM9668416 Model4_FPKM
- GSM9668417 Treatment1_FPKM
- GSM9668418 Treatment2_FPKM
- GSM9668419 Treatment3_FPKM
- GSM9668420 Treatment4_FPKM
- GSE295426 Targeting branched-chain amino acids alleviates pulmonary fibrosis [RNA-seq] 54 samples shares alleviates, targeting, acid
- GSE335983 Sedanolide alleviates LPS-induced depressive-like behaviors by modulating the C3a/C3aR signaling axis and microglial glycolysis 19 samples shares depressive-like, alleviates, behaviors
- GSE295425 Targeting branched-chain amino acids alleviates pulmonary fibrosis [CUT&Tag, histone_modification] 20 samples shares alleviates, targeting, acid
- GSE295423 Targeting branched-chain amino acids alleviates pulmonary fibrosis [ATAC-seq] 12 samples shares alleviates, targeting, acid
- GSE246252 Macrophage depletion alleviates pain-related behaviors in osteoarthritic mice 19 samples shares alleviates, behaviors
- GSE328634 Asiatic acid from Centella asiatica alleviates renal fibrosis: coordinated modulation of the gut–kidney axis and retinol metabolism 15 samples shares alleviates, acid
- GSE314668 Targeting cathepsin B alleviates activation of IL-17A-netrophils axis to suppress atopic dermatitis 12 samples shares alleviates, targeting
- GSE282783 Delayed crosstalk between astrocytes and neurons leads to depressive-like behaviors 12 samples shares depressive-like, behaviors
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.