Degradation of perineuronal nets in hippocampal CA2 explains the loss of social cognition memory in Alzheimer's disease
RNA-seq (gene expression) · mouse · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 16 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Degradation of perineuronal nets in hippocampal CA2 explains the loss of social cognition memory in Alzheimer's diseaseAlzheimer's & dementia : the journal of the Alzheimer's Association · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE317499_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1414267 and SRA study SRP666346. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 16 more — browse all 16 samples with per-sample file links →
- GSE283691 Dietary and exercise interventions improve cognition and alter hippocampal transcriptome in a metabolic syndrome mouse model 48 samples shares hippocampal, cognition
- GSE300348 Cdkn2a/p16INK4A Loss affects hippocampal transcription in Young Adult Mice Independently of Alzheimer ’s-Associated Genetic Pathways 23 samples shares hippocampal, alzheimer
- GSE279550 Neuronal APOE4-induced Early Hippocampal Network Hyperexcitability in Alzheimer’s Disease Pathogenesis 16 samples shares hippocampal, alzheimer
- GSE296390 p75 Neurotrophin Receptor Shapes the Dynamics of Adult Hippocampal Neurogenesis in Alzheimer's Disease 12 samples shares hippocampal, alzheimer
- GSE285078 MRTFA-SRF driven gene expression promotes cellular stiffness by controlling cytoplasmic Ca2+ and K+ levels in cancer cells II 36 samples shares ca2
- GSE283790 Effects of attenuating astrocytic Ca2+ activity in the medial prefrontal cortex with iβARK on transcriptional profiles in 5xFAD mice 25 samples shares ca2
- GSE305142 L-type voltage-gated Ca2+ channels control T cell killing via non-canonical Hedgehog signaling 24 samples shares ca2
- GSE220973 Mismatch repair protein MLH1 suppresses replicative stress in BRCA2 deficient breast tumors 23 samples shares ca2
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.