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FB23-2 exerts therapeutic effects against T-ALL through the FTO/m6A/MYC axis.

GSE317759 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2026/05/19 Platform GPL24676
Summary
T-cell acute lymphoblastic leukemia (T-ALL) is a pediatric hematological malignancy that presents significant challenges. RNA N6-methyladenosine (m6A) methylation is crucial in tumorigenesis, and the m6A demethylase FTO has emerging importance in cancers; however, its specific role in T-ALL pathogenesis remains incompletely understood. In vitro studies employed T-ALL cell lines treated with the FTO inhibitor FB23-2. Our findings indicate that FB23-2 may exert therapeutic effects against T-ALL primarily through the FTO/m6A/MYC axis.
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Also filed as BioProject PRJNA1415197 and SRA study SRP667817. Searching any of these in the dataset finder brings you back here.

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