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Effect of intrauterine growth restriction on the chromatin accessibility of microglia in hippocampus

GSE317920 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 8 samples Submitted 2026/01/30 Platform GPL18480
Summary
Early-life exposures (spanning from the gamete stage to childhood) to adverse environmental factors can exert long-term effects on offspring health through epigenetic modifications, significantly increasing susceptibility to chronic diseases such as neuropsychiatric disorders in adulthood. Previous studies have shown that fetal growth restriction can lead to excessive activation of microglia in the individual's brain, but there is still a lack of research on its epigenetic mechanisms. Our data supplements the changes in chromatin accessibility of microglia in the hippocampus of individuals with fetal growth restriction, and explores the epigenetic basis of microglial activation
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Also filed as BioProject PRJNA1415825 and SRA study SRP669126. Searching any of these in the dataset finder brings you back here.

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