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eIF4G2-mediated Translation Initiation of Histone Modifiers is Essential for Intestinal Stem Cell Maintenance and Differentiation [CUT&Tag]

GSE318066 Mus musculus (mouse) ChIP-seq / ATAC-seq (genome binding and open chromatin) 37 samples Submitted 2026/04/30 Platform GPL30172
At a glance

ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 37 samples

What it is
ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
Organism
Mus musculus (mouse)
Samples
37 samples: 11 conditions, mostly with about 4 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Summary (written by the submitters)
eIF4G2 (also known as NAT1, p97, and DAP5) is an evolutionally conserved protein homologous to the c-terminal two thirds portion of eukaryotic translation initiation factor (eIF) 4G. Despite its abundant and ubiquitous expression, physiological and pathological functions of eIF4G2 are poorly understood. Here we show that acute inactivation of eIF4G2 in adult mice results in rapid weight loss with abnormalities in multiple organs.
Read the full summary ↓
In this study, we show that eIF4G2 is critical for translation of key histone modification proteins involved in maintenance and differentiation of intestinal stem cells. Our study underscores the importance of eIF4G2-mediated translation in multicellular organisms.
This dataset
Open GSE318066 in finder → Find more mouse ChIP / ATAC / CUT&Tag datasets →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE318066_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.

Also filed as BioProject PRJNA1416404 and SRA study SRP670603. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗
Study design
11 conditions, mostly with about 4 replicates each
Heterozygous, H3K27ac, ×4 Homozygous, H3K27ac, ×4 Heterozygous, Ep300, ×4 Homozygous, Ep300, ×4 Heterozygous, Crebbp, ×4 Homozygous, Crebbp, ×4 Fetal, Heterozygous, H3K27ac, ×3 Fetal, Homozygous, H3K27ac, ×3 +3 more

Supports a between-group comparison across 37 samples.

How we read this: 11 replicated groups read from 37 sample titles; they account for 37 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study
Datasets on a similar topic

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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.