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Gene Expression profiling of TgCRND8 brains at 18 months

GSE318217 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2026/02/04 Platform GPL21626
Summary
Tau tangles and amyloid plaques are pathological hallmarkes of Alzheimer's disease (AD). To understand transcriptomics changes that occur in response to amyloid deposition, we have analyzed the brains of 18 month old mice from the TgCRND8 transgenic line which overexpresses APP and develop Thioflavin S-positive amyloid plaques beginning at 3 months of age.
Published in
Integrative proteomics identifies a conserved Aβ amyloid responsome, novel plaque proteins, and pathology modifiers in Alzheimer's disease
Levites Y, Dammer EB, Ran Y et al. · Cell reports. Medicine 2024 · PMID 39127040 · doi:10.1016/j.xcrm.2024.101669
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Also filed as BioProject PRJNA1416927 and SRA study SRP672116. Searching any of these in the dataset finder brings you back here.

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