Self-clustering of three CBX2 molecules drives PRC2 to promote facultative heterochromatinization of Polycomb target genes
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 33 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 33 samples: 15 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Self-clustering of three CBX2 molecules drives PRC2 to promote facultative heterochromatinization of Polycomb target genesMolecular cell · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE318279_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1418504 and SRA study SRP489181. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 2 samples read as cases, 1 as controls.
How we read this: 15 replicated groups read from 33 sample titles; they account for 32 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8073499 H3K27me3_D0_rep1 H3K27me3_D0
- GSM8073500 H3K27me3_D0_rep2 H3K27me3_D0
- GSM8073501 H3K27me3_D2_rep1 H3K27me3_D2
- GSM8073502 H3K27me3_D2_rep2 H3K27me3_D2
- GSM8073503 H3K27me3_D4_rep1 H3K27me3_D4
- GSM8073504 H3K27me3_D4_rep2 H3K27me3_D4
- GSM8073505 H3K27me3_D6_rep1 H3K27me3_D6
- GSM8073506 H3K27me3_D6_rep2 H3K27me3_D6
- GSM8073507 CBX2_CR_rep1 CBX2_CR
- GSM8073508 CBX2_CR_rep2 CBX2_CR
- GSM8073509 EZH2_CR_CBX2_WT_rep1 EZH2_CR_CBX2_WT
- GSM8073510 EZH2_CR_CBX2_WT_rep2 EZH2_CR_CBX2_WT
- GSM8073511 EZH2_CR_CBX2_KO_rep1 EZH2_CR_CBX2_KO
- GSM8073512 EZH2_CR_CBX2_KO_rep2 EZH2_CR_CBX2_KO
- GSM9491665 CBX2_KO_rep1 CBX2_KO
- GSM9491666 CBX2_KO_rep2 CBX2_KO
- GSM9491667 PGK_HT_CR_rep1 PGK_HT_CR
- GSM9491668 PGK_HT_CR_rep2 PGK_HT_CR
- GSM9491669 CBX2_CR_PSM_rep1 CBX2_CR_PSM
- GSM9491670 CBX2_CR_PSM_rep2 CBX2_CR_PSM
- GSM9491671 PGK_WT_CT_rep1
- GSM9491672 X2PSM_CT_rep1 X2PSM_CT
- GSM9491673 X2PSM_CT_rep2 X2PSM_CT
- GSM9491674 Micro-C, CBX2_WT_rep1 Micro-C, CBX2_WT
- GSM9491675 Micro-C, CBX2_WT_rep2 Micro-C, CBX2_WT
- GSM9491676 Micro-C, CBX2_WT_rep3 Micro-C, CBX2_WT
- GSM9491677 Micro-C, CBX2_KO_rep1 Micro-C, CBX2_KO
- GSM9491678 Micro-C, CBX2_KO_rep2 Micro-C, CBX2_KO
- GSM9491679 Micro-C, CBX2_KO_rep3 Micro-C, CBX2_KO
- GSM9491680 Cbx2 knock-in mESCs treated with EtOH as day 0 control, replicate1 Cbx2 knock-in mESCs tre…
- GSM9491681 Cbx2 knock-in mESCs treated with EtOH as day 0 control, replicate2 Cbx2 knock-in mESCs tre…
- GSM9491682 Cbx2 knock-in mESCs treated with OHT for 2 days to generate Cbx2 KO, replicate1 Cbx2 knock-in mESCs tre…
- GSM9491683 Cbx2 knock-in mESCs treated with OHT for 2 days to generate Cbx2 KO, replicate2 Cbx2 knock-in mESCs tre…
- GSE318276 Self-clustering of three CBX2 molecules drives PRC2 to promote facultative heterochromatinization of Polycomb target genes [Cut & Run, Cut & Tag] 9 samples shares cbx2, prc2, heterochromatinization, self-clustering, facultative, molecules, polycomb, promote
- GSE318278 Self-clustering of three CBX2 molecules drives PRC2 to promote facultative heterochromatinization of Polycomb target genes [RNA-Seq] 4 samples shares cbx2, prc2, heterochromatinization, self-clustering, facultative, molecules, polycomb, promote
- GSE255506 Sparse CBX2 nucleates many Polycomb proteins to promote facultative heterochromatinization of Polycomb target genes 14 samples shares cbx2, heterochromatinization, facultative, polycomb, promote
- GSE297309 SKP1A-mediated degradation of PRC2 triggers activation of Polycomb-silenced gene [CUT&Tag] 108 samples shares prc2, polycomb
- GSE286195 PRC2 Promotes Canalisation During Endodermal Differentiation 74 samples shares prc2, promote
- GSE297094 SKP1A-mediated degradation of PRC2 triggers activation of Polycomb-silenced gene [ChIP-seq 2] 73 samples shares prc2, polycomb
- GSE278724 Allosteric effectors of PRC2 synergise to restrict Polycomb domains spread 60 samples shares prc2, polycomb
- GSE55698 Variant PRC1 complex dependent H2A ubiquitylation drives PRC2 recruitment and polycomb domain formation 41 samples shares prc2, polycomb
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.