Sparse CBX2 nucleates many Polycomb proteins to promote facultative heterochromatinization of Polycomb target genes
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 14 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 14 samples: 7 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Self-clustering of three CBX2 molecules drives PRC2 to promote facultative heterochromatinization of Polycomb target genesMolecular cell · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE255506_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1075128 and SRA study SRP489181. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 14 samples.
How we read this: 7 replicated groups read from 14 sample titles; they account for 14 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8073499 H3K27me3_D0_rep1 H3K27me3_D0
- GSM8073500 H3K27me3_D0_rep2 H3K27me3_D0
- GSM8073501 H3K27me3_D2_rep1 H3K27me3_D2
- GSM8073502 H3K27me3_D2_rep2 H3K27me3_D2
- GSM8073503 H3K27me3_D4_rep1 H3K27me3_D4
- GSM8073504 H3K27me3_D4_rep2 H3K27me3_D4
- GSM8073505 H3K27me3_D6_rep1 H3K27me3_D6
- GSM8073506 H3K27me3_D6_rep2 H3K27me3_D6
- GSM8073507 CBX2_CR_rep1 CBX2_CR
- GSM8073508 CBX2_CR_rep2 CBX2_CR
- GSM8073509 EZH2_CR_CBX2_WT_rep1 EZH2_CR_CBX2_WT
- GSM8073510 EZH2_CR_CBX2_WT_rep2 EZH2_CR_CBX2_WT
- GSM8073511 EZH2_CR_CBX2_KO_rep1 EZH2_CR_CBX2_KO
- GSM8073512 EZH2_CR_CBX2_KO_rep2 EZH2_CR_CBX2_KO
- GSE318276 Self-clustering of three CBX2 molecules drives PRC2 to promote facultative heterochromatinization of Polycomb target genes [Cut & Run, Cut & Tag] 9 samples shares cbx2, heterochromatinization, facultative, polycomb, promote
- GSE318279 Self-clustering of three CBX2 molecules drives PRC2 to promote facultative heterochromatinization of Polycomb target genes 33 samples shares cbx2, heterochromatinization, facultative, polycomb, promote
- GSE318278 Self-clustering of three CBX2 molecules drives PRC2 to promote facultative heterochromatinization of Polycomb target genes [RNA-Seq] 4 samples shares cbx2, heterochromatinization, facultative, polycomb, promote
- GSE264193 H3K27 dimethylation dynamics reveal stepwise establishment of facultative heterochromatin in early mouse embryos [ChIP-seq] 57 samples shares facultative
- GSE263441 H3K27 dimethylation dynamics reveal stepwise establishment of facultative heterochromatin in early mouse embryos [RNA-Seq] 10 samples shares facultative
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.