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Bulk liver mRNA-seq of Cep72 knockout and wild-type mice in Schistosoma japonicum infection–induced and CCl4-induced liver fibrosis models

GSE318357 Mus musculus (mouse) RNA-seq (gene expression) 12 samples Submitted 2026/07/01 Platform GPL34290
At a glance

RNA-seq (gene expression) · mouse · 12 samples

What it is
RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
Organism
Mus musculus (mouse)
Samples
12 samples
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
Centrosomal protein 72 deficiency exacerbates liver fibrosis induced by Schistosoma japonicum infectionParasites & vectors · 2026
Summary (written by the submitters)
Liver fibrosis is a common pathological outcome of chronic liver injury triggered by diverse etiologies. To investigate the role of CEP72 in fibrogenesis under distinct fibrotic settings, we performed bulk mRNA sequencing of whole-liver total RNA from wild-type (WT) and Cep72 knockout (Cep72-KO) mice in two experimental models: Schistosoma japonicum (Sj) infection–induced liver fibrosis and carbon tetrachloride (CCl4)–induced liver fibrosis.
Read the full summary ↓
For the Sj model, mice were percutaneously infected with 17 ± 1 Schistosoma japonicum cercariae per mouse and analyzed at 8 weeks post infection, generating four groups: 8W-NC (WT control), 8W-KO-NC (Cep72-KO control), 8W-Sj (WT + Sj infection), and 8W-Sj-KO (Cep72-KO + Sj infection) (n = 2 mice per group). For the CCl4 model, mice were treated for 8 weeks with intraperitoneal injections of 10% CCl4 at 10 μL/g body weight, twice per week, and samples were collected from 8W-CCL4 (WT + CCl4) and 8W-KO-CCL4 (Cep72-KO + CCl4) groups (n = 2 mice per group). Paired-end Illumina mRNA-seq was performed on extracted total RNA from whole liver tissue. This dataset enables comparative transcriptomic analyses to identify CEP72-associated gene expression programs and pathways involved in liver injury, inflammation, and fibrosis across parasitic and chemical models.
Published in
Centrosomal protein 72 deficiency exacerbates liver fibrosis induced by Schistosoma japonicum infection
Fang Q, Mei G, Zhao X et al. · Parasites & vectors 2026 · PMID 42087233 · doi:10.1186/s13071-026-07372-7
This dataset
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE318357_RAW.tar (it can run to tens of gigabytes).

3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.

Also filed as BioProject PRJNA1418618 and SRA study SRP674565. Searching any of these in the dataset finder brings you back here.

Samples in this study

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+ 12 more — browse all 12 samples with per-sample file links →

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