← BioTransfer GEO Dataset Finder
GEO series

mRNA 3ʹ UTRs direct microRNA degradation to participate in imprinted gene networks and regulate growth

GSE318680 Mus musculus (mouse) Non-coding RNA profiling 129 samples Submitted 2026/04/08 Platform GPL24676Platform GPL24247Platform GPL34290Platform GPL17021
At a glance

Non-coding RNA profiling · mouse · 129 samples

What it is
Non-coding RNA profilingLevels of RNAs that do not code for proteins, such as miRNA or lncRNA.
Organism
Mus musculus (mouse)
Samples
129 samples: 38 conditions, mostly with about 4 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
mRNA 3' UTRs direct microRNA degradation to participate in imprinted gene networks and regulate growthGenes & development · 2026
SuperSeries — this record groups several sub-series.
Summary (written by the submitters)
This SuperSeries is composed of the SubSeries listed below.
Published in
mRNA 3' UTRs direct microRNA degradation to participate in imprinted gene networks and regulate growth
Lin DH, Elcavage LE, Khalizeva E et al. · Genes & development 2026 · PMID 41871909 · doi:10.1101/gad.353479.125
This dataset
Open GSE318680 in finder → Find more datasets →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE318680_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

Also filed as BioProject PRJNA1419756 and SRA study SRP675186. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 41871909) ↗
Study design
38 conditions, mostly with about 4 replicates each
mRNA E18.5 heart Lrrc58 hom Plagl1 WT ×7 mRNA E18.5 heart Lrrc58 het Plagl1 mut(pat) ×7 mRNA E18.5 heart Lrrc58 hom Plagl1 mut(pat) ×5 mRNA E18.5 heart Lrrc58 het Plagl1 WT ×5 sRNA MEF (15A3) Zswim8 knockout clone ×4 mRNA E18.5 stomach Plagl1 WT pup ×4 mRNA E18.5 stomach Plagl1 mut(pat) pup ×4 mRNA E18.5 lung Lrrc58 WT pup ×4 +31 more

Supports a case/control comparison: 30 samples read as cases, 42 as controls.

How we read this: 38 replicated groups read from 129 sample titles; they account for 128 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study

+ 89 more — browse all 129 samples with per-sample file links →

Datasets on a similar topic

Search all datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.