GAS deficient mice display premature aging associated with loss of chromatin organization, derepression of LINE1 elements and induction of inflammation [Cut & Tag]
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 14 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 14 samples: 14 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE318683_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1419772 and SRA study SRP675196. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 14 sample titles: 14 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9500710 Lung primary fibroblasts, cGAS KO, female 1, h3k27me3
- GSM9500711 Lung primary fibroblasts, cGAS KO, female 1, h3k9me3
- GSM9500712 Lung primary fibroblasts, cGAS KO, female 2, h3k27me3
- GSM9500713 Lung primary fibroblasts, cGAS KO, female 2, h3k9me3
- GSM9500714 Lung primary fibroblasts, cGAS KO, female 3, h3k27me3
- GSM9500715 Lung primary fibroblasts, cGAS KO, female 3, h3k9me3
- GSM9500716 Lung primary fibroblasts, cGAS KO, female 3, IgG
- GSM9500717 Lung primary fibroblasts, WT, female 1, h3k27me3
- GSM9500718 Lung primary fibroblasts, WT, female 1, h3k9me3
- GSM9500719 Lung primary fibroblasts, WT, female 2, h3k27me3
- GSM9500720 Lung primary fibroblasts, WT, female 2, h3k9me3
- GSM9500721 Lung primary fibroblasts, WT, female 3, h3k27me3
- GSM9500722 Lung primary fibroblasts, WT, female 3, h3k9me3
- GSM9500723 Lung primary fibroblasts, WT, female 3, IgG
- GSE279026 cGAS deficient mice display premature aging associated with loss of chromatin organization, derepression of LINE1 elements and induction of inflammation 33 samples shares line1, gas, organization, derepression, deficient, premature, chromatin, induction
- GSE279025 cGAS deficient mice display premature aging associated with loss of chromatin organization, derepression of LINE1 elements and induction of inflammation [RNA-seq] 11 samples shares line1, gas, organization, derepression, deficient, premature, chromatin, induction
- GSE269651 SP1 antagonizes H3K27me3 to shape chromatin landscapes for RNA polymerase II recruitment during gastrulation [RNA-seq] 32 samples shares gas, chromatin
- GSE294678 Dietary restriction mitigates vascular aging, modulates the cGAS-STING pathway and reverses macrophage-like VSMC phenotypes in progeroid DNA-repair-deficient Ercc1Δ/- mice 29 samples shares gas, deficient
- GSE320421 Hydroxychloroquine Alleviates Cyclophosphamide-Induced Premature Ovarian Failure by Attenuating Granulosa Cell Senescence and Modulating the mtDNA-cGAS Pathway 9 samples shares gas, premature
- GSE304211 H4K16ac contributes to chromatin compartment reorganization during mitotic and meiotic transitions [CUTnTAG] 128 samples shares organization, chromatin
- GSE284165 Reorganization of PBAF/cBAF remodelers on H3.3 chromatin regulates BMAL1 activity in the absence of circadian negative feedback 47 samples shares organization, chromatin
- GSE288731 Reorganization of H3K9me2-modified chromatin regions during mouse embryonic development 33 samples shares organization, chromatin
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.