Defining the acute BTK-loss transcriptional program in CLL using a BTK degrader
RNA-seq (gene expression) · human · 32 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Chronic lymphocytic leukemiaThis series is part of our curated briefing on it.
- Samples
- 32 samples: 5 conditions, mostly with about 4 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Defining the acute BTK-loss transcriptional program in CLL using a BTK degraderLeukemia · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE319429_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1423275 and SRA study SRP676855. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 32 samples.
How we read this: 5 replicated groups read from 32 sample titles; they account for 32 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9517856 AB1 AB
- GSM9517857 AB2 AB
- GSM9517858 AB3 AB
- GSM9517859 AB4 AB
- GSM9517860 MP1 MP
- GSM9517861 MP2 MP
- GSM9517862 MP3 MP
- GSM9517863 MP4 MP
- GSM9517864 LG1 LG
- GSM9517865 LG2 LG
- GSM9517866 LG3 LG
- GSM9517867 LG4 LG
- GSM9517868 WL1 WL
- GSM9517869 WL2 WL
- GSM9517870 WL3 WL
- GSM9517871 WL4 WL
- GSM9517872 ZWCT1847 ZWCT
- GSM9517873 ZWCT1848 ZWCT
- GSM9517874 ZWCT1849 ZWCT
- GSM9517875 ZWCT1850 ZWCT
- GSM9517876 ZWCT1851 ZWCT
- GSM9517877 ZWCT1852 ZWCT
- GSM9517878 ZWCT1853 ZWCT
- GSM9517879 ZWCT1854 ZWCT
- GSM9517880 ZWCT1855 ZWCT
- GSM9517881 ZWCT1856 ZWCT
- GSM9517882 ZWCT1857 ZWCT
- GSM9517883 ZWCT1858 ZWCT
- GSM9517884 ZWCT1859 ZWCT
- GSM9517885 ZWCT1860 ZWCT
- GSM9517886 ZWCT1861 ZWCT
- GSM9517887 ZWCT1862 ZWCT
- GSE330399 Molecular and Structural Basis of Pan-Resistance to BTK Inhibitors and Degraders 100 samples same disease briefing · shares btk, degrader
- GSE313098 Time-series RNA-seq analysis reveals dynamic transcriptional responses and crosstalk in chronic lymphocytic leukaemia (CLL) autologous and monoculture in vitro models 60 samples same disease briefing · shares cll
- GSE305855 Casein kinase 1δ/ε inhibition suppresses CLL through cell-intrinsic and microenvironmental mechanisms [RNA-Seq] 42 samples same disease briefing · shares cll
- GSE249956 Trascriptional profiling of proliferating and resting fracntions in ibrutinib-treated CLL 40 samples same disease briefing · shares cll
- GSE283045 PD-1 expression identifies activated and proliferating chronic lymphocytic leukemia cells and is a potential biomarker that informs response and resistance to BTK inhibitor therapy 35 samples same disease briefing · shares btk
- GSE293100 Modulation of NOTCH1 signaling in CLL and MCL cell lines 30 samples same disease briefing · shares cll
- GSE329311 B cell receptor-mediated amplification of the interferon response in CLL cells 12 samples same disease briefing · shares cll
- GSE277432 Aberrantly Expressed Mitochondrial Lipid Kinase, AGK Activates JAK2-Histone H3 Axis and BCR Signal: A Mechanistic Study with Implication in CLL Therapy 10 samples same disease briefing · shares cll
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.