Chronic PFOA and PFOS Exposure Triggers Cellular Oxidative Stress and Alters Lipid Levels as Revealed through Multi-omics Analysis
RNA-seq (gene expression) · human · 27 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 27 samples: 27 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Chronic PFOA and PFOS exposure triggers cellular oxidative stress and alters lipid levels as revealed through multi-omics analysisEnvironmental science. Advances · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE320486_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1425030 and SRA study SRP678124. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 27 sample titles: 27 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9544226 RNA-Seq of RPE cells exposed to PFOA at 24h (sample b)
- GSM9544227 RNA-Seq of RPE cells exposed to PFOS at 24h (sample b)
- GSM9544228 RNA-Seq of RPE cells exposed to PFOS at 17w (sample a)
- GSM9544229 RNA-Seq of RPE cells exposed to PFOA at 17w (sample a)
- GSM9544230 RNA-Seq of RPE cells exposed to PFOA at 24h (sample c)
- GSM9544231 RNA-Seq of RPE cells exposed to PFOS at 24h (sample c)
- GSM9544232 RNA-Seq of RPE cells exposed to PFOS at 17w (sample b)
- GSM9544233 RNA-Seq of RPE cells exposed to MeOH (control) at 24h (sample b)
- GSM9544234 RNA-Seq of RPE cells exposed to PFOA at 17w (sample b)
- GSM9544235 RNA-Seq of RPE cells exposed to PFOS at 24h (sample a)
- GSM9544236 RNA-Seq of RPE cells exposed to PFOA at 24w (sample a)
- GSM9544237 RNA-Seq of RPE cells exposed to PFOS at 17w (sample c)
- GSM9544238 RNA-Seq of RPE cells exposed to MeOH (control) at 24h (sample c)
- GSM9544239 RNA-Seq of RPE cells exposed to MeOH (control) at 24h (sample a)
- GSM9544240 RNA-Seq of RPE cells exposed to PFOA at 24h (sample a)
- GSM9544241 RNA-Seq of RPE cells exposed to PFOS at 7w (sample a)
- GSM9544242 RNA-Seq of RPE cells exposed to PFOS at 7w (sample b)
- GSM9544243 RNA-Seq of RPE cells exposed to PFOA at 7w (sample c)
- GSM9544244 RNA-Seq of RPE cells exposed to PFOS at 7w (sample c)
- GSM9544245 RNA-Seq of RPE cells exposed to PFOA at 24w (sample b)
- GSM9544246 RNA-Seq of RPE cells exposed to PFOA at 17w (sample c)
- GSM9544247 RNA-Seq of RPE cells exposed to PFOA at 24w (sample c)
- GSM9544248 RNA-Seq of RPE cells exposed to PFOS at 24w (sample b)
- GSM9544249 RNA-Seq of RPE cells exposed to PFOA at 7w (sample a)
- GSM9544250 RNA-Seq of RPE cells exposed to PFOA at 7w (sample b)
- GSM9544251 RNA-Seq of RPE cells exposed to PFOS at 24w (sample a)
- GSM9544252 RNA-Seq of RPE cells exposed to PFOS at 24w (sample c)
- GSE292721 Oxidative stress-regulatory role of miR-10b-5p in the diabetic human cornea revealed through integrated multi-omics analysis 16 samples shares multi-omics, oxidative, revealed
- GSE315651 Perfluorooctane sulfonate (PFOS) in follicular fluid and human granulosa cell dysfunction: a physiologically based toxicokinetic model translation of low-level, long-term in vitro exposure data 32 samples shares pfos, exposure
- GSE342612 Transcriptomic and H3K27ac chromatin responses of human microglia to acute PFOS exposure and recovery 36 samples shares pfos, exposure
- GSE297039 Multi-omics Analysis Revealed Unique Features of Age-associated Type2 CD8 Memory T cells 30 samples shares multi-omics, revealed
- GSE311040 Multi-omics integrative approach of senescent endothelial cells and derived extracellular vesicles in a replicative senescence model 18 samples shares multi-omics, cellular
- GSE271689 Enhancing Immunotherapy Outcomes: Spatial Multi-Omics Predictive Models for Non-Small Cell Lung Cancer 586 samples shares multi-omics
- GSE263083 Multi-omics data analysis for the JGOG3025-TR2 ovarian cancer cohort [RNA-seq] 291 samples shares multi-omics
- GSE260603 Dissecting depression symptoms: multi-omics clustering uncovers immune-related subgroups and cell-type specific dysregulation 273 samples shares multi-omics
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.