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B4GALT1 deficiency attenuates steatohepatitis by regulating the PPARγ/ACSL4 axis

GSE324244 Mus musculus Expression profiling by high throughput sequencing 7 samples Submitted 2026/03/25 Platform GPL24247
Summary
Metabolic dysfunction-associated fatty liver disease (MASLD) can progress to metabolic dysfunction-associated steatohepatitis (MASH) and fibrosis. Previous studies have implicated aberrant glycosylation in MASLD progression. However, the role and underlying molecular mechanisms of B4GALT1 in MASLD progression remain unclear. Our studies demonstrate that B4GALT1 plays a crucial role in MASLD progression by targeting lipid peroxidation in hepatocytes via the PPARγ/ACSL4 axis, thus highlighting a potential therapeutic target for MASLD.
Published in
B4GALT1 deficiency attenuates steatohepatitis by regulating the PPARγ/ACSL4 axis
Chien Y, Xia R, Zhou D et al. · Hepatology communications 2026 · PMID 41860570 · doi:10.1097/HC9.0000000000000920
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Also filed as BioProject PRJNA1434295 and SRA study SRP682167. Searching any of these in the dataset finder brings you back here.

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