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Cross-Species Transcriptomic Integration Reveals a Conserved, MIRO1-Mediated Macrophage-to-T Cell Signaling Axis Driving Immunosuppression in Glioma [snRNA-Seq]

GSE324504 Mus musculus Expression profiling by high throughput sequencing 5 samples Submitted 2026/03/12 Platform GPL24247
Summary
We generated single-nucleus RNA sequencing (snRNA-seq) data from murine gliomas treated in vivo with a MIRO1-binding compound or vehicle control. Tumors were dissociated and processed for nucleus isolation followed by high-throughput transcriptomic profiling to characterize cell-type-specific gene expression programs within the tumor microenvironment (TME). The dataset captures malignant cells and diverse stromal and immune populations, including macrophages, microglia, and T cells, enabling analysis of treatment-associated transcriptional changes at single-cell resolution. These data provide a resource for investigating mitochondrial-associated transcriptional regulation and immune microenvironment remodeling in murine glioma.
Published in
Cross-species transcriptomic integration reveals a MIRO1-mediated macrophage-T cell axis in glioma
Du Z, Li M, Bergsneider BH et al. · Life science alliance 2026 · PMID 42128668 · doi:10.26508/lsa.202603749
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Also filed as BioProject PRJNA1435645 and SRA study SRP682797. Searching any of these in the dataset finder brings you back here.

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