GEO series
Transcriptomic changes in primary human keratinocytes following exposure to lamotrigine, lamotrigine-N2-oxide, lamotrigine in combination with valproic acid or interferon-γ, and interferon-γ alone
GSE324594
Homo sapiens
Expression profiling by high throughput sequencing
36 samples
2026/03/30
GPL24676
Summary
Bulk RNA sequencing with differential expression analysis was used to examine transcriptional changes in keratinocytes after exposure to lamotrigine (LTG), its CYP-mediated metabolite LTG-N2-oxide, and co-incubated LTG with valproic acid (VPA). IFN-γ served as a positive control, as its effects on keratinocytes are well documented.
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Paper (PMID 41910223) ↗
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