GEO series
Epidermal growth factor dampens pro-inflammatory gene expression induced by interferon-gamma in global transcriptome analysis of keratinocytes
GSE279122
Homo sapiens
Expression profiling by high throughput sequencing
12 samples
2025/01/09
GPL21290
Summary
The impact of EGFR ligands (i.e. EGF) on interferon signaling is unclear. The purpose of this study was to investigate the impact of EGF on IFN-γ transcriptional responses on a genome-wide scale in keratinocytes. RNA-seq was performed in human keratinocyte (HaCaT) cells treated with IFN-γ, EGF, both, or neither (control). Differentially expressed genes (DEGs) in each treatment group, relative to control, were identified using DESeq2. Our findings suggest that the pro-inflammatory IFN-γ-induced transcriptome may be globally attenuated by EGF in keratinocytes, supporting an anti-inflammatory role of EGF in the skin.
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Paper (PMID 39924511) ↗
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