Epidermal growth factor dampens pro-inflammatory gene expression induced by interferon-gamma in global transcriptome analysis of keratinocytes
RNA-seq (gene expression) · human · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 12 samples: 12 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Epidermal growth factor dampens pro-inflammatory gene expression induced by interferon-gamma in global transcriptome analysis of keratinocytesBMC genomics · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE279122_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1170914 and SRA study SRP537400. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 12 sample titles: 12 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8561792 1_untreated_cells_R1
- GSM8561793 2_EGF_treated_cells_R1
- GSM8561794 3_IFNgamma_treated_cell_R1
- GSM8561795 4_EGF_IFNgamma_treated_cells_R1
- GSM8561796 5_untreated_cells_R2
- GSM8561797 6_EGF_treated_cells_R2
- GSM8561798 7_IFNgamma_treated_cell_R2
- GSM8561799 8_EGF_IFNgamma_treated_cells_R2
- GSM8561800 9_untreated_cells_R3
- GSM8561801 10_EGF_treated_cells_R3
- GSM8561802 11_IFNgamma_treated_cell_R3
- GSM8561803 12_EGF_IFNgamma_treated_cells_R3
- GSE292207 Functional interaction of Epidermal growth factor and Angiotensin II in female human primary vascular smooth muscle cells 44 samples shares epidermal, growth, factor
- GSE269700 "Hepatocyte growth factor has a unique function in keratinocytes that differs from IL-17A and TNF-aand may contribute to the severity of hidradenitis suppurativa.” 24 samples shares keratinocytes, growth, factor
- GSE289787 Candida albicans and Staphylococcus aureus reciprocally promote their virulence factor secretion and pro-inflammatory effects 44 samples shares pro-inflammatory, factor
- GSE255546 Crosstalk in Skin: Loss of Desmoglein 1 in Keratinocytes Inhibits BRAFV600E-induced Cellular Senescence in Human Melanocytes 18 samples shares keratinocytes, induced
- GSE289231 DIFFERENTIAL TEMPERATURE-INDUCED RESPONSES IN ORAL AND SKIN KERATINOCYTES 18 samples shares keratinocytes, induced
- GSE289113 Synergistic Effects of Retinol and Retinyl Palmitate in Alleviating UVB-Induced DNA Damage and Promoting the Homologous Recombination Repair in Keratinocytes 15 samples shares keratinocytes, induced
- GSE252347 RNA-Seq of human cutaneous squamous cell carcinoma cell lines and normal human epidermal keratinocytes. 12 samples shares keratinocytes, epidermal
- GSE244738 Highly concentrated trehalose prevents IL-4/IL-13-induced skin barrier impairment by suppressing IL-33 expression and increasing Nrf2 activation in epidermal keartinocytes 12 samples shares epidermal, induced
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.