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Ngn3 reprograms late retinal progenitor cells through transcriptional and epigenetic mechnisms [RNA-Seq]

GSE326387 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/04/24 Platform GPL34328
Summary
Ngn family transcription factors exhibit potent capacity to promote neurogenesis under diverse cellular context. Using in vivo electroporation on newbone mouse pups retinas, we demonstrate that overexpression of Ngn3 (Ngn3-OE) reprogramms the differentiation competent status of late retinal progenitor celle (RPC), promoting rod photoreceptor differentiation while repressing the fates of Müller glial cell and other interneurons. Herein, we perform RNA-seq and ATAC-seq to investigate the underlying molecular mechanism by which Ngn3 reprogramms late RPCs.
Published in
Ngn3 Regulates Differentiation Competence of Retinal Progenitor Cells Through Transcriptional and Epigenetic Modification
Chen C, Liang H, He Q et al. · International journal of molecular sciences 2026 · PMID 42123429 · doi:10.3390/ijms27093845
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Also filed as BioProject PRJNA1445195 and SRA study SRP687776. Searching any of these in the dataset finder brings you back here.

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