Skin-resident Langerhans Cells Drive Neuropathic Pain via Chemokine-Dependent Neuron-Immune Communication
Single-cell RNA-seq · mouse · 12 samples
- What it is
- Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart. Read from the summary: GEO's own type field only says 'expression profiling by sequencing', so confirm it in the paper.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 3 × Male RD paw epidermis vs 3 × Male HFD paw epidermis vs 3 × Female RD paw epidermis vs 3 × Female HFD paw epidermisGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Skin-resident Langerhans cells drive neuropathic pain via chemokine-dependent neuron-immune communicationThe Journal of clinical investigation · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE327170_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1449593 and SRA study SRP689680. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9650445 Male RD paw epidermis replicate 1 Male RD paw epidermis
- GSM9650446 Male RD paw epidermis replicate 2 Male RD paw epidermis
- GSM9650447 Male RD paw epidermis replicate 3 Male RD paw epidermis
- GSM9650448 Male HFD paw epidermis replicate 1 Male HFD paw epidermis
- GSM9650449 Male HFD paw epidermis replicate 2 Male HFD paw epidermis
- GSM9650450 Male HFD paw epidermis replicate 3 Male HFD paw epidermis
- GSM9650451 Female RD paw epidermis replicate 1 Female RD paw epidermis
- GSM9650452 Female RD paw epidermis replicate 2 Female RD paw epidermis
- GSM9650453 Female RD paw epidermis replicate 3 Female RD paw epidermis
- GSM9650454 Female HFD paw epidermis replicate 1 Female HFD paw epidermis
- GSM9650455 Female HFD paw epidermis replicate 2 Female HFD paw epidermis
- GSM9650456 Female HFD paw epidermis replicate 3 Female HFD paw epidermis
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- GSE275841 MYC-Driven Gliosis Impairs Neuron-Glia Communication in Amyotrophic Lateral Sclerosis 32 samples shares communication, drive
- GSE221698 Chromatin Remodeling Drives Immune-Fibroblast Cell Communication in Heart Failure (scRNA-Seq) 22 samples shares communication, drive
- GSE221696 Chromatin Remodeling Drives Immune-Fibroblast Cell Communication in Heart Failure (scATAC-Seq) 9 samples shares communication, drive
- GSE247261 Chromatin Remodeling Drives Immune-Fibroblast Cell Communication in Heart Failure [scRNA-Seq] 6 samples shares communication, drive
- GSE221695 Chromatin Remodeling Drives Immune-Fibroblast Cell Communication in Heart Failure (Cut & Run) 4 samples shares communication, drive
- GSE92522 Transcriptional architecture of synaptic communication delineates cortical GABAergic neuron identity 46 samples shares communication
- GSE310829 Non-reciprocal callosal projections and input gradients underlie interhemispheric communication in binocular visual cortex 41 samples shares communication
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.