GEO series
Reprogramming Dedifferentiation Regulatory Networks Preserves Human Chondrocyte Phenotypes (RNA-Seq)
GSE327285
Homo sapiens
Expression profiling by high throughput sequencing
12 samples
2026/04/14
GPL20795
Summary
Chondrocyte-based cartilage repair strategies such as autologous chondrocyte implantation (ACI) require extensive in vitro expansion to obtain clinically relevant cell numbers. However, monolayer expansion drives chondrocyte dedifferentiation, reducing matrix-forming capacity and contributing to variable repair outcomes, a long-standing problem in cell-based cartilage repair.
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