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RNA binding protein YWHAZ mediates translation of specific mRNA and regulates cell Proliferation and apoptosis in diabetic foot ulcer

GSE327462 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/07/29 Platform GPL34284
Summary
YWHAZ was a significantly up-regulated and validated RBP in DFU by RT-qPCR and immunohistochemistry. Cellular experiments revealed that Si_YWHAZ facilitated proliferation and migration while inhibiting apoptosis, consistent with its upregulation in DFU. RNA-seq identified 1072 DEGs in Si_YWHAZ cells. Up-regulated genes were significantly enriched in cell proliferation-related processes and included AREG, FOSL1, HAS2 and IL7R, whereas down-regulated genes were associated with cell adhesion, such as LAMB3, SLAMF7, COL12A1 and ITGA5. IRIP-seq results demonstrated that YWHAZ interacts with plentiful of mRNAs and genomic location toward the CD and introns region. As well, ABLIFE algorithm indicated that YWHAZ bound to GC-rich motifs. Integrated iRIP-seq and RNA-seq analyses identified 57 DEGs that were selectively bound by YWHAZ, most of which were down-regulated. Notably, SREBF1, which was positively associated with type 2 diabetes risk. KEGG pathway analysis revealed SREBF1 is enriched in insulin resistance and insulin signaling pathway
Published in
RNA binding protein YWHAZ mediates specific mRNA translation and regulates cell proliferation and apoptosis in diabetic foot ulcer
Zha T, Yao J, Wang H et al. · Frontiers in medicine 2026 · PMID 42180716 · doi:10.3389/fmed.2026.1751279
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Also filed as BioProject PRJNA1450981 and SRA study SRP690455. Searching any of these in the dataset finder brings you back here.

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