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A novel autopolysialylation activity of the ganglioside sialyltransferase ST8Sia5 regulates its secretion and enzyme activity

GSE327613 Mus musculus Expression profiling by high throughput sequencing 3 samples Submitted 2026/06/18 Platform GPL23479
Summary
This study showed that ST8Sia5L is a novel self-polysialylating enzyme that modifies itself rather than NCAM. We found that this autopolysialylation regulates both the secretion of ST8Sia5L from cells and its conventional ganglioside-sialylation activity. These results suggest that polysialylation of ST8Sia5L plays an important role in controlling its function and extracellular behavior.
Published in
A novel autopolysialylation activity of the ganglioside sialyltransferase ST8Sia5 regulates its secretion and enzyme activity
Sakamoto F, Hatanaka R, Hane M et al. · The Journal of biological chemistry 2026 · PMID 42103213 · doi:10.1016/j.jbc.2026.113106
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Also filed as BioProject PRJNA1451527 and SRA study SRP690801. Searching any of these in the dataset finder brings you back here.

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