GEO series
Murine Endothelial Chromatin Remodeling Enzymes Modulate Plasmin Activity and Sterile Inflammation to Prevent Lethal Embryonic Liver Deterioration
GSE327619
Mus musculus
Expression profiling by high throughput sequencing
24 samples
2026/05/12
GPL24247
Summary
Transcriptional changes in liver sinusoidal endothelial cells (LSECs) from mutant mouse embryos lacking endothelial chromatin-remodeling enzymes need investigation. In this study, we compared the transcriptomes of CD146+ LSECs and the non-EC liver cells from control, Chd4fl/fl;Brg1fl/+;VE-cadherin-Cre+, Chd4fl/+;Brg1fl/fl;VE-cadherin-Cre+, and Chd4fl/fl;Brg1fl/fl;VE-cadherin-Cre+ mice at embryonic day 12.5. Our results show that inflammation-related gene expression is upregulated in endothelial mutants lacking Chd4 and returns to normal when both Chd4 and Brg1 are deleted.
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